Wolfgang Sippl Selected Research

Nervous System Diseases (Neurological Disorders)

12/2023	Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors.
12/2023	Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor.
1/2023	Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors.
1/2018	Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation.
1/2017	Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold.

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Wolfgang Sippl Research Topics

Disease

69	Neoplasms (Cancer) 01/2024 - 05/2007
9	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 01/2008
9	Alzheimer Disease (Alzheimer's Disease) 04/2023 - 09/2018
9	Schistosomiasis (Bilharziasis) 01/2022 - 01/2013
6	Parasitic Diseases (Parasitic Disease) 01/2022 - 07/2015
5	Nervous System Diseases (Neurological Disorders) 12/2023 - 01/2017
5	Neuroblastoma 07/2022 - 12/2017
4	Infections 01/2023 - 02/2014
4	Breast Neoplasms (Breast Cancer) 01/2022 - 03/2008
4	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 01/2012
3	Metabolic Diseases (Metabolic Disease) 01/2024 - 01/2008
3	Neglected Diseases 01/2022 - 01/2016
3	Neoplasm Metastasis (Metastasis) 01/2020 - 04/2014
3	Carcinogenesis 01/2020 - 07/2015
3	Malaria 01/2017 - 12/2013
3	Inflammation (Inflammations) 02/2016 - 02/2015
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2023 - 01/2022
2	Hematologic Neoplasms (Hematological Malignancy) 11/2023 - 07/2023
2	Mental Disorders (Mental Disorder) 08/2022 - 08/2003
2	Leukemia 01/2022 - 01/2009
2	Leishmaniasis 10/2020 - 01/2017
2	Cardiovascular Diseases (Cardiovascular Disease) 10/2019 - 12/2011
2	Trypanosomiasis 01/2017 - 10/2007
2	Pathologic Processes 11/2010 - 10/2010
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2024
1	Ovarian Neoplasms (Ovarian Cancer) 11/2023
1	avian vacuolar myelinopathy 10/2023
1	Multiple System Atrophy 10/2023
1	Hypokinesia (Bradykinesia) 10/2023
1	Tremor (Tremors) 10/2023
1	Colorectal Neoplasms (Colorectal Cancer) 07/2023
1	Adenocarcinoma 07/2023
1	Chagas Disease (American Trypanosomiasis) 01/2023
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2023
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022
1	Echinococcosis (Hydatid Cysts) 01/2022
1	Cysticercosis 01/2022
1	Amyloidosis 01/2022
1	Edema (Dropsy) 08/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 04/2021
1	Parkinson Disease (Parkinson's Disease) 07/2020
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2020

Drug/Important Bio-Agent (IBA)

23	Histone Deacetylases (Histone Deacetylase)IBA 11/2023 - 07/2015
14	SirtuinsIBA 01/2024 - 01/2008
13	EnzymesIBA 11/2023 - 03/2008
11	Histone Deacetylase InhibitorsIBA 11/2023 - 02/2009
11	Proteins (Proteins, Gene)FDA Link 07/2023 - 01/2009
11	Histones (Histone)IBA 04/2021 - 05/2007
6	Phosphotransferases (Kinase)IBA 01/2024 - 01/2014
6	Praziquantel (Biltricide)FDA Link 01/2022 - 01/2013
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2023 - 01/2017
5	TubulinIBA 11/2023 - 03/2008
5	Lysine (L-Lysine)FDA Link 01/2022 - 09/2013
4	Sirtuin 2IBA 11/2023 - 02/2015
4	Hormones (Hormone)IBA 09/2013 - 08/2007
3	N-Methylaspartate (NMDA)IBA 12/2023 - 01/2017
2	Proteolysis Targeting ChimeraIBA 01/2024 - 07/2022
2	Histone Deacetylase 6IBA 11/2023 - 01/2023
2	LigandsIBA 07/2023 - 05/2021
2	Cholinesterases (Cholinesterase)IBA 01/2023 - 01/2022
2	Protein Kinases (Protein Kinase)IBA 01/2022 - 04/2014
2	ZincIBA 01/2022 - 01/2016
2	EsterasesIBA 01/2022 - 01/2016
2	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2022 - 01/2016
2	VaccinesIBA 10/2020 - 12/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 05/2011
2	Protein Kinase InhibitorsIBA 12/2017 - 04/2014
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 07/2015
2	Histone DemethylasesIBA 01/2016 - 12/2012
2	AndrogensIBA 09/2013 - 01/2012
2	Histone MethyltransferasesIBA 12/2012 - 01/2009
1	Ionotropic Glutamate ReceptorsIBA 12/2023
1	AMPA Receptors (AMPA Receptor)IBA 12/2023
1	AcidsIBA 12/2023
1	ProdrugsIBA 11/2023
1	NeurotoxinsIBA 10/2023
1	aetokthonotoxinIBA 10/2023
1	Biomarkers (Surrogate Marker)IBA 10/2023
1	Hydroxamic Acids (Hydroxamic Acid)IBA 07/2023
1	Retinal Pigments (Pigments, Visual)IBA 07/2023
1	Third Generation CephalosporinsIBA 04/2023
1	Cephalosporins (Cephalosporin Antibiotics)IBA 04/2023
1	benzonidazole (benznidazole)IBA 01/2023
1	PyrazinesIBA 01/2023
1	IsoenzymesIBA 07/2022
1	CarbamatesIBA 01/2022
1	Tyrosine (L-Tyrosine)FDA Link 01/2022
1	entinostat (MS 275)IBA 01/2022
1	Memantine (Namenda)FDA Link 01/2022
1	Donepezil (Aricept)FDA LinkGeneric 01/2022
1	AnthelminticsIBA 01/2022
1	Indomethacin (Indometacin)FDA LinkGeneric 08/2021
1	CarrageenanIBA 08/2021
1	ChromatinIBA 05/2021
1	AmidesIBA 05/2021
1	Glucose (Dextrose)FDA LinkGeneric 04/2021
1	ellagitanninIBA 08/2020

Therapy/Procedure

18	Therapeutics 10/2023 - 04/2012
2	Drug Therapy (Chemotherapy) 01/2016 - 12/2013
1	Autonomic Denervation 10/2023